Welcome To EONS! (Elementary Objects of the Nervous System)
Our research focus consists in modeling hippocampal synaptic nonlinear dynamics and understanding their challenging complexity. Such modeling consists in understanding the role of the elements that comprise a synapse and participate in the transmission of information from the presynaptic terminal to post-synaptic density and more generally from a neuron to another. This also involves understanding the different interactions that exist between these elements and how geometry affects synaptic response.
Our research is done through a modeling platform called EONS (Elementary Objects of the Nervous System). This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more.
EONS v1.1.3 is the perfect tool to study the basic interactions between synaptic elements in a friendly manner. There are no complicated equations to write: all the models are predefined! This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.