I.02. Other mammalian

PBS video on the role of PKM-zeta in memory

This is a 10-minute PBS Nova video on memory formation and consolidation. It introduces H.M., the Scoville surgery, and Milner's studies (incuding a nice video of the motor learning experiment). It has a segment on the thin-slicing, staining, and digitization of H.M.'s brain. It has an animation of synaptic transmission and introduces the idea that memory has molecular and anatomic bases. It emphasizes (perhaps too much) the role of PKM-zeta in memory.

 

Nervous System

 

Basic Anatomy Using Sheep Brain Specimen. This allows you to test your hand at identifying 30 major brain structures viewed in midsaggital section of sheep brain.
 

 

A self-study tutorial using the Allen Brain Explorer and Brain Atlas to teach concepts of mammalian neuroanatomy and brain function.

Jenks, Bruce G. (2009). A self-study tutorial using the Allen Brain Explorer and Brain Atlas to teach concepts of mammalian neuroanatomy and brain function.The Journal of Undergraduate Neuroscience Education, 8(1): A21-A25. ISBN: 15442896

Two photon laser scan imaging of a cerebellar purkinje neuron

This purkinje neuron from a mouse cerebellum was imaged with the fluorescent dye Alexa 594, injected into the cell with a microelectrode. The high resolution image was captured with a two photon laser scanning microscope. The microscope took two dimensional images of the neuron, and then advanced deeper into the tissue, one micron at a time, taking many more scans. The computer took the stack of images and reconstructed the 3D video you see here.

Two photon laser scan imaging of dendritic spine activity

This is a small dendritic branch from a Layer 3 neuron in the mouse auditory cortex. The neuron has been filled with a red fluorescent dye (Alexa 594), which is why it appears red on the video. It has also been filled with a calcium sensitive green fluorescent dye (Fluo 5F). When neurons from the thalamus are stimulated (during the yellow dot on the video), you will see that one of the dendritic spines (shown by the arrow) glows green, showing that it is being activated by thalamic stimulation.

Neuroanatomy labs and integrative exercises

Description: This resource is a guide designed to supplement a typical upper level Physiological Psychology or Behavioral Neuroscience course or to serve as a stand-alone, expandable laboratory experience. The guide includes 10 assignments, answer keys, and references that reinforce and expand upon students' learning and stimulate interesting class discussions.

Sheep brain dissection guide

The plan in approaching the problem of dissecting the sheep's brain is the following: First, an examination of the external features of the specimen will be undertaken. Second, the brain will be bisected along the longitudinal midline, and the several features of the medial face of the hemisphere considered. Third, the brain will be sectioned in a coronal manner, and the deep structures of the brain studied from that point of view. (For your dissection you will use only the right hemisphere of the brain for your coronal sections).

Cow's Eye Dissection

At the Exploratorium, we dissect cows’ eyes to show people how an eye works. This Web site shows photos and videos of a dissection. If you try this at home, wash your hands after the dissection. Wear latex gloves if you have cuts in your hands.

High Resolution Mouse Brain Atlas

The general goals of the High Resolution Brain Atlas project are 1) to construct atlases of the brain of the mouse, an animal that is becoming increasingly important for neuroscience, particularly because of its position as the mammal of choice in genetic research, and 2) to use the brain of this small, relatively inexpensive and readily available animal as the test case on which to work out issues of capture and integration of multidisciplinary data, of 3D reconstruction from serial slices, and of data dissemination, in the expectation that the lessons learned will become applicable dir

Comparative Mammalian Brain Collection

This web site provides browsers with images and information from one of the world's largest collection of well-preserved, sectioned and stained brains of mammals. Viewers can see and download photographs of brains of over 100 different species of mammals (including humans) representing over 20 Mammalian Orders.

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